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KMID : 1189420080210020046
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2008 Volume.21 No. 2 p.46 ~ p.53
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The Effects of Sunbanghwalmyung-eum Extract on Anti-oxidant, Anti-allergic and Anti-inflammatory ability in mouse cell
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Park Min-Cheol
Hong Seung-Ug
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Abstract
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Background and Objectives : The aim of this study was to investigate the anti-oxidant, anti-allergic and anti-inflammatory ability of the Taglisodog-eum(SHE) extract on the RAW 264.7 and EL4 cells
Materials and Methods : Three types of experiments were implemented for this study: first, the experiment to study the anti-oxidant effect of SHE using Riboflavin; second, in vitro experiment to investigate the inhibition of Th 2 cell differentiation by SHE using EL4 cells (IL-4 mRNA expression); third, the suppression of activation using RAW 264.7 cells (iNOS and COX-2 mRNA expression).
Results : The anti-oxidant ability of SHE were dose-dependantly increased. From in vitro, the LPS-induced iNOS and COX-2 mRNA expression were dose-dependantly decreased in the RAW264.7 cells treated with SHE and the PMA-induced IL-4 mRNA expression were also dose-dependantly decreased in EL4 cells. activation was suppressed, and iNOS & COX-2 production were inhibited by SHE
Conclusion : The results suggest that SHE has dose-dependant anti-oxidant ability, and has anti-allergic and anti-inflammatory effects through the suppression of activation and the inhibition of Th 2 cell differentiation.
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KEYWORD
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Sunbanghwalmyung-eum, anti-oxidant, anti-inflammatory, Th 2
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